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Combo-pilling will be the newest fad or also the newest in the future under scrutiny and so it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that as of right now there aren't any long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartrate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. --Participating in support groups which help the family with the addict recover (for example Al-Anon or Nar-Anon).